The drug "Nise" (tablets): composition, properties and indications for use

To date, there are many drugs that have anti-inflammatory properties. And not the last place in the rating of the most effective medicines is occupied by "Nise". Tablets really quickly help to eliminate the main symptoms of certain diseases. Therefore, many patients are interested in information about the composition and properties of the drug, as well as possible side effects.

"Nise" (tablets): composition and the form of

This drug is available in the form of round biconvex tablets with a smooth surface and a white and sometimes yellowish tinge. The main active substance in this case is nimesulide. Each tablet contains 100 mg of the main active ingredient. As for excipients, corn starch, magnesium stearate,calcium hydrosulfate, sodium carboxymethyl starch, microcrystalline cellulose, as well as talc and colloidal silicon dioxide.

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The main properties of the drug

Naturally, its medicinal properties are due to nimesulide and the peculiarities of its effect on the human body. This drug is nothing more than a non-steroidal anti-inflammatory agent. Nimesulide selectively inhibits certain enzymes that are involved in the synthesis of prostaglandins, which are also called mediators of inflammation and pain. Moreover, the drug acts not only directly at the site of inflammation, but also blocks the conduction of pain impulses in the spinal cord. Thus, the drug not only relieves inflammation, but also eliminates pain. In addition, nimesulide inhibits the release of histamine during an allergic reaction and prevents the destruction of cartilage tissue. The maximum concentration of the main active substance in the blood is observed 1.5-2.5 hours after administration. The drug and its metabolites do not accumulate in the body - they are rapidly excreted by the kidneys.

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Indications for use

Of course, many patients are interested in the question of when to take "Nise" (pills). What does this drug help? First of all, it is used for various systemic disorders and diseases of the musculoskeletal system. In particular, the medicine helps to relieve pain and reduce inflammation in rheumatoid arthritis, as well as gout, which is accompanied by severe joint pain. In addition, the drug is used to treat arthritis of a different origin, in particular, caused by psoriasis. The indications for admission are strong muscle pain, regardless of the cause of their occurrence. Medicine "Nise" is often taken by people with diseases such as myalgia, neuralgia, bursitis, osteoarthritis, tendvaginitis, osteoarthritis, tendonitis. As a first aid pill is used for various injuries, for example, bruises, tears and sprains.nise pills from whatThe drug is able to eliminate the pain of almost any genesis, including headaches and teeth, discomfort during menstruation, postoperative discomfort. And since the drug has persistent anti-inflammatory and antipyretic properties, it is prescribed for infectious diseases accompanied by inflammation and fever.

Nise tablets: instructions for use

Of course, it is recommended to take the drug after prior consultation with the doctor, as the specialist must assess your health condition, as well as determine the absence of contraindications. For children over twelve years of age and adult patients, the recommended dose is one tablet twice a day. In the most severe cases, the daily rate can be increased to four tablets. They should be taken either before meals or after meals, drinking plenty of water.

niz tablets instructions for use

Are there any contraindications?

Not all patients can take the drug "Nise". Tablets are primarily contraindicated in patients with allergies to any of the components of the drug. In addition, certain diseases of the digestive tract, including ulcerative lesions and the presence of bleeding, are contraindications. The drug is not prescribed to people with acute hepatic and renal failure. The drug should also not be taken in people with decompensated heart failure, progressive diseases of the excretory system, inflammatory bowel diseases, including ulcerative colitis and Crohn's disease. Alcoholism and drug addiction are also contraindications.The drug is not used to treat children under twelve years of age, as well as pregnant women and mothers who are breastfeeding. The drug is prescribed with caution to people with diabetes, congestive heart failure, vascular diseases.

Possible side effects

Immediately it is worth noting that the adverse reactions caused by the intake of this anti-inflammatory agent are not recorded very often. However, the use of pills can lead to the following disorders:

  • In some cases, the drug causes an allergic reaction, accompanied by urticaria, anaphylaxis, angioedema.
  • Rarely there is dizziness, headaches, drowsiness, nervousness, nightmares.
  • Taking the drug in some patients may cause edema, impaired kidney function, including urinary retention, interstitial nephritis, and renal failure.
  • The most common side effects are nausea, vomiting and diarrhea. More rarely, therapy is associated with constipation and flatulence. Occasionally, patients have abdominal pain, ulcerative lesions of the digestive tract, bleeding, gastritis.
  • In some cases, medication affects the liver. Side effects include cholestasis, fulminant jaundice and hepatitis.
  • "Nise" can cause disorders of the respiratory and cardiovascular systems, including bronchospasm, shortness of breath, arterial hypertension, tachycardia and hemorrhage.
  • Other side effects include blurred vision, anemia, hypothermia, and general weakness.

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Drug overdose: symptoms and treatment

Of course, excessive consumption of the drug is fraught with overdose. Its symptoms include nausea, vomiting, drowsiness, apathy. In some cases, bleeding may occur in the gastrointestinal tract. The drug "Nise" (pills) can also increase blood pressure, cause acute renal failure. At the first sign of the patient must be taken to the hospital. There is no specific antidote to this remedy; therefore, supportive and symptomatic therapy is carried out. If after an excessive intake of the drug, no more than four hours have passed, then a gastric lavage is performed, and the patient is prescribed laxatives and sorbents (activated carbon).

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Some additional information about the drug

Since the medication can cause an attack of dizziness, drowsiness and weakness, then after taking it is not recommended to drive a car or work with mechanisms that require an accurate and quick reaction. It is worth noting that old age is a relative contraindication - such patients require constant supervision. With long-term use of medication, the doctor should regularly check the work of the kidneys and liver.

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